Cleaning products for nosocomial infections do not disinfect – Contagio Vive

One of the current challenges facing healthcare facilities is the prevention of fungal and bacterial infections and their transmission within these facilities. To reduce transmissions within facilities, appropriate cleaning mechanisms have been implemented.

Especially when patients are faced with a hospital-acquired infection (HAI) such as Clostridioides difficile infection (CDI) , hospitals use disinfectants such as chlorine-releasing agents (CRAs) and hydrogen peroxide to decontaminate surfaces, including beds, bathrooms, and other areas . in the areas reserved for patients. In addition, the gowns of hospital staff and patients should also be cleaned with strong cleaning agents.

A new study examined sodium hypochlorite (NaOCl), also known as bleach, and the effect on spore response to clinical concentrations of the cleaner applied to hospital gowns. The researchers found that the cleaner does not kill C-diff spores. ¹

What do you want to know

The study finds that sodium hypochlorite, commonly used as a disinfectant in healthcare settings, is not effective at killing C-diff spores.

The results highlight the need for disinfectants and guidelines specifically designed to combat evolving bacterial strains, given the increasing prevalence of antimicrobial resistance.

The study raises further questions about biocide tolerance within C diff and raises the question of whether disinfectant tolerance is influenced by antibiotic co-tolerance.

"As the prevalence of antimicrobial resistance increases, the threat to human health from superbugs increases," observed Tina Joshi, associate professor of molecular microbiology at the University of Plymouth, with fourth-year medical student Humaira Ahmed. "This study highlights the ability of C-diff spores to tolerate disinfection during use and highlights recommended active chlorine concentrations. It shows that we need disinfectants and policies adapted to their use," a medical school student said in a statement to University Peninsula. and work in harmony with bacterial evolution, and the research is expected to have a significant impact on current medical disinfection protocols worldwide. ¹

Study details
The new study examined the response of spores from three different C diff strains to three clinical concentrations of sodium hypochlorite used.
"Spores from strains R20291, DS1813 and CD630 [ C diff strains] were independently exposed to 1,000, 5,000 and 10,000 ppm at a concentration of 1 × 108 spores per ml-1," the researchers wrote. "NaOCl in liquid form for 10 minutes (recommended contact time) and the biocidal activity was neutralized with an equal volume of 5 gl-1 sodium thiosulfate for 10 minutes contact time to remove any residual biocidal activity of chlorine." ²

The spores were then detected on surgical gowns and patient gowns and examined using scanning electron microscopes to determine whether there were morphological changes in the outer layer of the spores. ¹

The study was conducted by researchers at the University of Plymouth in England and they reported that C diff spores were not affected at all despite the high levels of bleach treatment used in many hospitals. In fact, researchers said chlorinated chemicals are no more effective at causing spore damage when used as surface disinfectants than when used with water without additives. ¹

"This study highlights the ability of C difficile spores to tolerate disinfection with NaOCl at the recommended concentrations of active chlorine during application," the researchers wrote. "Understanding the molecular basis of these interactions is critical for the practical treatment of CDI and for reducing the burden of infection in healthcare settings. " ²

The researchers point out another important factor. In particular, the need to answer questions about biocide tolerance in C difficile and whether biocide tolerance is influenced by antibiotic co-tolerance. ²

reference

1. A study found that chlorine disinfectants are no more effective at killing hospital superbugs. Society for Microbiology. November 22, 2023. Accessed December 14, 2023. https://microbiologysociety.org/news/press-releases/chlorine-disinfectant-is-no-more-effective-than-water-at-killing-off-hospital- superbug - study shows. HTML

2. Ahmed H, Joshi LT. Clostridioides difficile spores tolerate disinfection with sodium hypochlorite and remain viable on surgical gowns and gown fabrics. Microbiology (reading) . 2023;169(11):001418. doi:10.1099/mic.0.001418 https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.001418

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